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Bioorg Med Chem. 2001 Feb;9(2):503-10.

Cysteinyl peptide inhibitors of Bacillus cereus zinc beta-lactamase.

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Department of Chemical and Biological Sciences, University of Huddersfield, Queensgate, UK.


Several cysteinyl peptides have been synthesised and shown to be reversible competitive inhibitors of the Bacillus cereus metallo-beta-lactamase. The pH dependence of pKi indicates that the thiol anion displaces hydroxide ion from the active site zinc(II). D,D-Peptides bind to the enzyme better than other diastereoisomers, which is compatible with the predicted stereochemistry of the active site.

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