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Nat Immunol. 2000 Aug;1(2):107-11.

Homeostasis of alpha beta TCR+ T cells.

Author information

1
Howard Hughes Medical Institute, University of Colorado Health Sciences Center, Denver, CO 80206, USA. marrackp@nuc.org

Abstract

Cytokines contribute to T cell homeostasis at all stages of T cell existence. However, the particular cytokine involved varies as T cells progress from a naïve through an activated to a memory state. In many cases the important cytokines are members of the interleukin 2 subfamily of the short-chain type I cytokines. A case is made for the idea that the evolutionary divergence of the short-chain family allowed for concurrent divergence in leukocytes.

PMID:
11248801
DOI:
10.1038/77778
[Indexed for MEDLINE]

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