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Curr Opin Cell Biol. 2001 Apr;13(2):225-31.

DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme?

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Wellcome Trust and Cancer Research Campaign Institute of Cancer and Developmental Biology, University of Cambridge, Tennis Court Road, CB2 1QR, Cambridge, UK.


The DNA damage signalling pathway is a core element of the cellular response to genotoxic insult, and its components play key roles in defending against neoplastic transformation. Recent work has indicated that the human ATM and ATR proteins, and their yeast homologues, are intimately involved in sensing DNA damage, suggesting parallels with the DNA double-strand break repair enzyme DNA-PK.

[Indexed for MEDLINE]

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