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Curr Opin Cell Biol. 2001 Apr;13(2):218-24.

HATs on and beyond chromatin.

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Department of Biological Chemistry, UC Davis Cancer Center/Basic Science Program, University of California at Davis, Sacramento, California 95817, USA.


The role of histone acetylation as a key mechanism of transcriptional regulation has been well established. Recent advances suggest that histone acetyltransferases also play important roles in histone-modulated processes such as DNA replication, recombination and repair. In addition, acetylation of transcriptional cofactors and other proteins is an efficient means of regulating a diverse range of molecular interactions. As new histone acetyltransferases and substrates are rapidly emerging, it is becoming apparent that protein acetylation may rival phosphorylation as a mechanism to transduce cellular regulatory signals.

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