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Genomics. 2001 Feb 15;72(1):51-60.

High-resolution mapping of the blood pressure QTL on chromosome 7 using Dahl rat congenic strains.

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1
Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo, Ohio 43614, USA.

Abstract

It was previously shown using Dahl salt-sensitive (S) and salt-resistant (R) rats that a blood pressure quantitative trait locus (QTL) was present on rat chromosome 7. In the present work, this QTL was localized to a region less than 0.54 cM in size on the linkage map using a series of congenic strains. This region was contained in a single yeast artificial chromosome that was 220 kb long. This small segment still contained the primary candidate locus Cyp11b1 (11beta-hydroxylase), but the adjacent candidate genes Cyp11b2 (aldosterone synthase) and Cyp11b3 were ruled out. It is concluded that 11beta-hydroxylase, through its known genetic variants altering the production of 18-hydroxy-11-deoxy corticosterone, is very likely to account for the blood pressure QTL on chromosome 7 in the Dahl rat model of hypertension. This QTL accounts for about 23 mm Hg under the condition of 2% NaCl diet for 24 days.

PMID:
11247666
DOI:
10.1006/geno.2000.6442
[Indexed for MEDLINE]
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