Format

Send to

Choose Destination
See comment in PubMed Commons below
J Rheumatol. 2001 Feb;28(2):406-12.

Minimal clinically important differences: review of methods.

Author information

1
Department of Epidemiology and Community Medicine, Faculty of Medicine, University of Ottawa, Ontario, Canada. gwells@uottawa.ca

Abstract

Determining a minimal clinically important difference to be detected in a clinical trial is a critical methodological step in the design of a study. In this review, the different methods that have been used in detecting important changes or differences are considered and categorized according to a classification system consisting of which groups are contrasted, the setting of the results, and the type of change of difference being quantified. It was found that most methods and procedures for deriving minimal clinically important differences considered important changes from the viewpoint of a group of patients. Development of methods that focus on individuals should be a goal of the future.

PMID:
11246688
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Support Center