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Ann Hum Genet. 1999 Nov;63(Pt 6):535-8. doi: 10.1017/S0003480099007824.

Hardy-Weinberg quality control.

Author information

1
Human Genetics, University of Southhampton, Duthie Building, southhampton General Hospital, Tremona Road, Southhampton, UK.

Abstract

An efficient test of deviation from Hardy-Weinberg frequencies with one degree of freedom was applied to 44 marker loci in a genome scan, and 7 loci had a significant excess of apparent homozygotes (chi2 (1) > 6) suggestive of typing error. In this example evidence for linkage did not increase when outliers were censored. Statistical quality control is an essential part of genotyping, and the effect of mistyping and map error should be considered in evaluating any genome scan.

PMID:
11246455
DOI:
10.1017/S0003480099007824
[Indexed for MEDLINE]
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