Format

Send to

Choose Destination
See comment in PubMed Commons below
Brain Res Mol Brain Res. 2001 Mar 5;87(2):246-50.

Molecular targets of disulfiram action on song maturation in zebra finches.

Author information

1
College de France, U 536 INSERM, 11 Place Marcellin Berthelot, Paris 75005, France.

Abstract

Disulfiram, an aldehyde dehydrogenase inhibitor, interferes with normal song maturation when applied to brain nucleus HVC of male zebra finches. We present here evidence from Western blots and enzymatic assays showing that known disulfiram targets other than retinaldehyde-specific aldehyde dehydrogenase (zRalDH) are absent in HVC. These findings are consistent with the conclusion that disulfiram disrupts song maturation by interfering with retinoic acid production.

PMID:
11245927
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center