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Frequent exposure of mice to crude Brucella abortus proteins down-regulates immune response.

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Department of Microbiology, Faculty of Biological Sciences, Universidad de Concepción, PO Box 152-C, Concepción, Chile.


Mice repeatedly immunized via the intraperitoneal route with a Brucella abortus antigen lost their ability to develop a strong in vitro lymphoproliferative response. This result correlates with a decreased tendency of the lymphoid population to produce interferon-gamma when stimulated in culture with the immunizing antigen. With respect to the humoral response, as the number of immunizations increased, the animals produced more specific immunoglobulin M and immunoglobulin G1 antibodies. It is postulated that the long-term exposure of an animal to Brucella antigen changes the nature of the immune response from a T-cell-mediated response to a humoral response favouring the establishment of the disease.

[Indexed for MEDLINE]

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