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Chest. 2001 Mar;119(3):973-5.

Pregnancy and primary pulmonary hypertension : successful outcome with epoprostenol therapy.

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Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Texas Medical Branch, Galveston, TX, USA.


Primary pulmonary hypertension (PPH) associated with pregnancy carries a high maternal mortality rate. Short-term epoprostenol infusion has been demonstrated to improve the hemodynamic profile in patients with PPH. We report a successful maternal-fetal outcome with epoprostenol therapy during pregnancy, cesarean section, and postpartum in a patient with PPH. Epoprostenol therapy did not produce any physical or developmental abnormalities in the fetus. A favorable maternal-fetal outcome may occur with a multidisciplinary approach.

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