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Psychopharmacology (Berl). 2001 Feb;153(4):455-63.

The effects of excitotoxic lesions of the nucleus accumbens core or shell regions on intravenous heroin self-administration in rats.

Author information

1
Department of Experimental Psychology, University of Cambridge, UK.

Abstract

RATIONALE:

It has been suggested that the nucleus accumbens (NAcc) may be involved in heroin reward, and the core and shell regions respond differently following administration of a number of drugs of abuse.

OBJECTIVE:

The possible role of the NAcc core and shell subregions in the acquisition of heroin self-administration behaviour was investigated.

METHODS:

Rats were given selective excitotoxic lesions of either the nucleus accumbens core or shell before the acquisition of responding for i.v. heroin (0.04 mg/infusion) under a continuous reinforcement schedule in daily 3 h sessions. After sham-lesioned rats reached a stable baseline, a between-sessions heroin dose-response function was established.

RESULTS:

Rats with lesions of the NAcc shell did not differ significantly from sham controls in either the acquisition of heroin self-administration or in their heroin dose-response function. The NAcc core lesion group showed reduced levels of responding during the acquisition of heroin self-administration and a reduction in responding during the heroin dose-response function, although this behaviour was sensitive to changes in the dose of heroin.

CONCLUSIONS:

The NAcc shell does not appear to be critical for heroin self-administration, whereas the NAcc core, although apparently not essential in mediating the rewarding effect of i.v. heroin, may mediate processes that are of special importance during the acquisition of instrumental behaviour.

PMID:
11243493
DOI:
10.1007/s002130000634
[Indexed for MEDLINE]

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