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J Nutr. 2001 Mar;131(3s):968S-71S. doi: 10.1093/jn/131.3.968S.

Determination of allicin, S-allylcysteine and volatile metabolites of garlic in breath, plasma or simulated gastric fluids.

Author information

1
Center for Advanced Food Technology, Cook Campus, Rutgers University, New Brunswick, NJ 08901, USA. rosen@aesop.rutgers.edu

Abstract

Various components of garlic and aged garlic extract, including allicin, S-allylcysteine (SAC) and volatile metabolites of allicin were determined in breath, plasma and simulated gastric fluids by HPLC, gas chromatography (GC) or HPLC- and GC-mass spectrometry (MS). Data indicate that allicin decomposes in stomach acid to release allyl sulfides, disulfides and other volatiles that are postulated to be metabolized by glutathione and/or S-adenosylmethionine to form allyl methyl sulfide. SAC can be absorbed by the body and can be determined in plasma by HPLC or HPLC-MS using atmospheric pressure chemical ionization (APCI)-MS.

PMID:
11238798
DOI:
10.1093/jn/131.3.968S
[Indexed for MEDLINE]

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