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Johns Hopkins Med J. 1975 Apr;136(4):183-6.

Acute codeine overdose: correspondence between clinical course and codeine metabolism.


A patient presented with clinical features of drug overdose. Although heroin was suspected, codeine was identified by drug analysis. The clinical course was complicated by shock, respiratory arrest and laboratory evidence of acute hepatic insufficiency. An inital slow rate of codeine metaboism, possibly related to the hepatic damage, corresponded to prolonged respiratory depression.

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