Format

Send to

Choose Destination
Biofactors. 2000;13(1-4):271-6.

Antiplatelet and anticancer isothiocyanates in Japanese domestic horseradish, wasabi.

Author information

1
Laboratory of Food and Biodynamics, Nagoya University Graduate School of Bioagricultural Sciences, Japan. monyan@cc.ocha.ac.jp

Abstract

6-Methylsulfinylhexyl isothiocyanate (MS-ITC) was isolated from wasabi (Wasabia japonica, Japanese domestic horseradish) as a potential inhibitor of human platelet aggregation in vitro through our extensive screening of vegetables and fruits. In the course of another screening for the induction of glutathione S-transferase (GST) activity in RL34 cells. MS-ITC was inadvertently isolated from wasabi as a potential inducer of GST. MS-ITC administered to rats or mice also showed both activities in vivo. As a result from elucidation of the platelet aggregation inhibition and the GST induction mechanisms of MS-ITC, the isothiocyanate moiety of MS-ITC plays an important role for antiplatelet and anticancer activities because of its highly reactivity with sulfhydryl (-SH) groups in biomolecules (GSH, cysteine residue in a certain protein, etc.).

PMID:
11237193
DOI:
10.1002/biof.5520130141
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center