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Nature. 2001 Feb 15;409(6822):947-8.

A physical map of human chromosome 14.

Author information

1
Genoscope and CNRS UMR 8030, Evry, France.

Abstract

We report the construction of a tiling path of around 650 clones covering more than 99% of human chromosome 14. Clone overlap information to assemble the map was derived by comparing fully sequenced clones with a database of clone end sequences (sequence tag connector strategy). We selected homogeneously distributed seed points using an auxiliary high-resolution radiation hybrid map comprising 1,895 distinct positions. The high long-range continuity and low redundancy of the tiling path indicates that the sequence tag connector approach compares favourably with alternative mapping strategies.

PMID:
11237018
DOI:
10.1038/35057177
[Indexed for MEDLINE]

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