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Arch Pathol Lab Med. 2001 Mar;125(3):404-5.

Low triglyceride levels affect calculation of low-density lipoprotein cholesterol values.

Author information

1
Clincal Laboratories, Sinlau Christian Hospital, Tainan, Taiwan. twang@ms26.url.com.tw

Abstract

The Friedewald formula for the calculation of low-density lipoprotein cholesterol (LDL-C) values is fairly accurate provided the triglyceride value is less than 400 mg/dL. It is not clear whether the estimation is also valid in the presence of low triglyceride and high cholesterol levels. We describe herein a patient with a low triglyceride value of approximately 50 mg/dL, a high cholesterol level, and a discrepant LDL-C level. The LDL-C level using the Friedewald calculation turned out to be much higher than the LDL-C level using direct measurement. We, therefore, suggest that in the presence of low triglyceride and high cholesterol levels, the LDL-C level should be measured directly instead of using the Friedewald calculation.

[Indexed for MEDLINE]

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