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Curr Biol. 2001 Jan 23;11(2):R63-6.

Molecular evolution: Please release me, genetic code.

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  • 1Department of Biological Sciences, The University at Albany, State University of New York, 1400 Washington Avenue, Albany, New York 12222, USA.


The genetic code is no longer universal, even in non-mitochondrial genomes. Recent studies have implicated the eukaryotic release factor eRF1 in mediating coding changes that are not as inconceivable as once thought. Specific residues in eRF1 proteins can be correlated with specific code changes in a wide variety of taxa.

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