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Curr Biol. 2001 Jan 23;11(2):R49-52.

Clathrin uncoating: Auxilin comes to life.

Author information

1
Department of Molecular Biology and Microbiology, Case Western Reserve, University School of Medicine, 10900 Euclid Avenue, Cleveland, Ohio 44106-4960, USA. skl@po.cwru.edu

Abstract

The DnaJ protein auxilin has been extensively studied in vitro as a cofactor for uncoating clathrin-coated vesicles by the chaperone Hsc70. Recent studies provide the first evidence that auxilin plays this role in vivo, and work on a new mammalian auxilin suggests the protein may have more complex cellular functions.

PMID:
11231140
[Indexed for MEDLINE]
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