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Bioorg Med Chem Lett. 2001 Feb 26;11(4):467-70.

Beta-D-glycosylamidines: potent, selective, and easily accessible 1-glycosidase inhibitors.

Author information

1
Institute for Chemical Research, Kyoto University, Uji, Kyoto, Japan.

Abstract

Beta-D-glycosylamidines, in which a glycon is connected via an N-glycoside linkage with a substituted amidine (aglycon), were synthesized in two steps from the corresponding sugars and served as stable and potent beta-glycosidase inhibitors with high selectivity according to the glycon- and alpha, beta-specificities of the enzymes.

PMID:
11229749
DOI:
10.1016/s0960-894x(00)00706-x
[Indexed for MEDLINE]

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