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Biol Cell. 2000 Oct;92(7):477-94.

Focal adhesions: structure and dynamics.

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Subcellular structure and cellular dynamics, UMR 144, CNRS-institut Curie, Paris, France.


Interactions of cells with the extracellular matrix are essential for the control of tissue remodelling, cell migration, and embryogenesis. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where transmembrane adhesion receptors provide a structural link between the actin cytoskeleton and the extracellular matrix components. Numerous structural and regulatory proteins assemble at the cytoplasmic face of focal adhesions in a Rho-dependent fashion.

[Indexed for MEDLINE]

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