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Curr Opin Immunol. 2001 Apr;13(2):166-71.

Pluripotent hematopoietic stem cell development during embryogenesis.

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  • 1Unité du Développement des Lymphocytes, Institut Pasteur, 25 Rue du Dr Roux, 75724, Paris, France.


Significant progress has been made towards a better understanding of the establishment of hematopoiesis in the embryo. Hematopoietic precursors have been shown to arise independently in the yolk sac and in the intra-embryonic mesoderm. From the combined analysis of differentiation potentials, expression patterns and mutant phenotypes, a picture has emerged: definitive hematopoietic precursors are transiently generated in a specific environment close to the endothelium of the main arteries.

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