Recognition of tumor cells by the innate immune system

M J Soloski

doi:10.1016/s0952-7915(00)00198-9

Recognition of tumor cells by the innate immune system

Curr Opin Immunol. 2001 Apr;13(2):154-62. doi: 10.1016/s0952-7915(00)00198-9.

Author

M J Soloski¹

Affiliation

¹ Division of Rheumatology and the Program in Immunology, Department of Medicine, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA. mski@jhmi.edu

PMID: 11228407
DOI: 10.1016/s0952-7915(00)00198-9

Abstract

There has been a rapid increase in our understanding of the cellular components of the innate immune system, the receptors used to distinguish changes in homeostasis, and how these components integrate into an anti-tumor effector response. Recently, significant progress has been made in the identification of ligands for receptors that activate NK cells, and the results have implications for the recognition of tumor cells.

Publication types

Review

MeSH terms

Adaptor Proteins, Signal Transducing
Animals
Cytotoxicity, Immunologic
Humans
Killer Cells, Natural / immunology*
Killer Cells, Natural / metabolism
Membrane Proteins
Neoplasms / immunology*
Receptors, Immunologic / immunology*
Receptors, Immunologic / metabolism
Receptors, Natural Killer Cell
T-Lymphocytes / immunology
T-Lymphocytes / metabolism

Substances

Adaptor Proteins, Signal Transducing
Membrane Proteins
Receptors, Immunologic
Receptors, Natural Killer Cell
TYROBP protein, human