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Microbes Infect. 2001 Jan;3(1):43-8.

Immunity and protection against Brucella abortus.

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Division of Hematology, Office of Blood and Blood Research, Center for Biologics Research and Review, Food and Drug Administration, 1401 Woodmont, Rockville Pike, MD 20852, USA.


Brucella abortus is an intracellular pathogen that causes disease in cattle and in humans. The response against B. abortus involves the whole gamut of the immune system, from innate to adaptive immunity resulting from stimulation of antigen-presenting cells, NK cells, CD4(+) and CD8(+) T cells, and B cells.

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