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Virus Res. 2001 Apr;74(1-2):133-7.

Localization of a new neutralizing epitope on the mumps virus hemagglutinin-neuraminidase protein.

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Department of Molecular Biology, Section of Microbiology, University of Siena, Via Laterina, 8-53100, Siena, Italy.


Four protein fragments which span the entire hemagglutinin-neuraminidase protein (HN) of mumps virus were expressed in HeLa cells and cell extracts were tested for their capability to induce neutralizing antibodies in mice. Fragment HN3 (aa 213-372) was able to induce the production of hemagglutination-inhibiting and neutralizing antibodies. When a subfragment of HN3, the synthetic peptide NSTLGVKSAREF (aa 329-340 of HN) was used for immunization, hemagglutination-inhibiting and neutralizing antibodies against mumps wild type virus but not against the Urabe Am9 vaccine virus were raised. The peptide could, therefore, contain a new epitope, which may be critical for protective host humoral immune response.

[Indexed for MEDLINE]

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