Format

Send to

Choose Destination
Nat Immunol. 2001 Mar;2(3):235-41.

Inactivation of Notch 1 in immature thymocytes does not perturb CD4 or CD8T cell development.

Author information

1
Ludwig Institute for Cancer Research, University of Lausanne, Epalinges, Switzerland.

Erratum in

  • Nat Immunol 2001 May;2(5):467.

Abstract

Notch proteins influence cell-fate decisions in many developing systems. Several gain-of-function studies have suggested a critical role for Notch 1 signaling in CD4-CD8 lineage commitment, maturation and survival in the thymus. However, we show here that tissue-specific inactivation of the gene encoding Notch 1 in immature (CD25+CD44-)T cell precursors does not affect subsequent thymocyte development. Neither steady-state numbers nor the rate of production of CD4+ and CD8+ mature thymocytes is perturbed in the absence of Notch 1. In addition, Notch 1-deficient thymocytes are normally sensitive to spontaneous or glucocorticoid-induced apoptosis. In contrast to earlier reports, these data formally exclude an essential role for Notch 1 in CD4-CD8 lineage commitment, maturation or survival.

Comment in

PMID:
11224523
DOI:
10.1038/85294
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center