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Biol Signals Recept. 2001 Jan-Apr;10(1-2):66-80.

Peroxynitrite-mediated mitochondrial dysfunction.

Author information

1
Institut National de la Santé et de la Recherche Médicale U408 and IFR 02, Faculté X. Bichat, Paris, France. jbb2@bichat.inserm.fr

Abstract

Peroxynitrite anion (ONOO(-)) is a potent biological oxidant produced by the near diffusion-limited reaction of superoxide and nitric oxide. Peroxynitrite has been implicated in diverse forms of free radical-induced tissue injury. Experimental evidence showed that exogenous and endogenous peroxynitrite causes alterations of the structure and function of mitochondrial proteins, leading to mitochondrial dysfunction and cellular or organ injury. These data are discussed along with its physiopathological implications.

PMID:
11223641
DOI:
10.1159/000046876
[Indexed for MEDLINE]

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