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FEBS Lett. 2001 Feb 16;490(3):153-62.

Making decisions through Myc.

Author information

1
Centro Acidi Nucleici CNR, Dipartimento di Genetica e Biologia Molecolare, Università La Sapienza, P.le A. Moro 5, 00185, Rome, Italy. s.nasi@caspur.it

Abstract

c-Myc is a transcriptional regulator involved in carcinogenesis through its role in growth control and cell cycle progression. Here we attempt to relate its role in stimulating the G1-S transition to the ability to affect functioning of key cell cycle regulators, and we focus on how its property of modulating transcription of a wide range of target genes could explain its capacity to affect multiple pathways leading to proliferation, apoptosis, growth, and transformation.

PMID:
11223030
DOI:
10.1016/s0014-5793(01)02118-4
[Indexed for MEDLINE]
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