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Neurology. 2001 Feb 27;56(4):529-30.

Antibodies to brain antigens following stroke.

Author information

1
Stroke Unit, Tel Aviv Sourasky Medical Center, Israel.

Abstract

Cerebral necrosis following stroke exposes brain antigens to the immune system, potentially initiating an antibody response. The authors measured levels of antibodies to specific neuronal antigens, neurofilaments (NF), and a ubiquitous antigen, cardiolipin (CL), in 45 patients following an acute first-ever stroke, within 48 hours, and 1, 3, and 6 months later. The mean levels of anti-NF antibodies were elevated compared with baseline at 1, 3, and 6, months (p = 0.012, 0.002, and 0.003 by paired t-test). Anti-CL levels did not change significantly.

PMID:
11222800
DOI:
10.1212/wnl.56.4.529
[Indexed for MEDLINE]

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