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J Chromatogr A. 2001 Jan 12;906(1-2):379-97.

Enantioselective chromatography as a powerful alternative for the preparation of drug enantiomers.

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NOVARTIS Pharma AG, Pharmaceutical Research, Core Technology, Basel, Switzerland.


The preparative separation of enantiomers by chromatography on chiral stationary phases (CSPs) has been recognized as being a useful alternative to the more conventional approaches such as enantioselective synthesis and enzymatically catalyzed transformations. The possible contribution of enantioselective chromatography with respect to the preparation of enantiomerically pure compounds is reviewed in the context of the competitive approaches and depending on the application scale, with a special emphasis on the recent progresses achieved in this particular field of separation.

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