Format

Send to

Choose Destination
Lancet. 2001 Jan 27;357(9252):280-1.

Increased mitochondrial toxicity with ribavirin in HIV/HCV coinfection.

Abstract

In two of 15 patients coinfected with HIV and hepatitis C virus who received interferon-alpha plus ribavirin in addition to HAART, we observed multiorgan dysfunction and lactic acidaemia. As ribavirin is a nucleoside analogue, an increased risk of mitochondrial toxicity can be induced in HIV-infected patients already treated with nucleoside analogues, leading to clinical deterioration in some cases.

PMID:
11214134
DOI:
10.1016/S0140-6736(00)03618-7
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center