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Lancet. 2001 Jan 20;357(9251):196-7.

Prevention of hepatocellular carcinoma in patients with chronic active hepatitis C and cirrhosis.

Abstract

In a prospective randomised controlled study, 90 patients with chronic active hepatitis C and compensated cirrhosis were assigned symptomatic treatment or interferon alfa (IFN-alpha). We report data on decompensation, detection of hepatocellular carcinoma, and mortality rates. IFN-alpha gave a sustained response in only a small proportion of patients, but worsening of compensated cirrhosis was prevented and development of hepatocellular carcinoma was inhibited, increasing the survival rate. The risk ratio of IFN-alpha versus symptomatic treatment decreased by 0.250 for progression to Child-Pugh grade B, 0.256 for detection of hepatocellular carcinoma, and 0.135 for a fatal outcome.

PMID:
11213099
DOI:
10.1016/S0140-6736(00)03595-9
[Indexed for MEDLINE]
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