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Cell Mol Life Sci. 1999 Oct 30;56(5-6):473-80.

The hypocretins/orexins: novel hypothalamic neuropeptides involved in different physiological systems.

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1
Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA. llecea@scripps.edu

Abstract

The hypothalamus regulates diverse physiological functions, including the control of energy metabolism, circadian rhythms, stress and anxiety, sexual and reproductive behaviors. An overview of the most prevalent hypothalamus-enriched mRNAs revealed that this area of the brain specializes in producing intercellular signaling molecules. Two new secreted peptides derived from a single neuropeptide precursor, named hypocretins and orexins by two different groups, are synthesized in a small set of neurons in the perifornical area of the hypothalamus. Intracerebroventricular injection of the hypocretins/orexins increases food consumption in rats. Here we review recent progress in identifying the role of the hypocretins/orexins in the control of energy balance and in other physiological systems.

PMID:
11212299
[Indexed for MEDLINE]
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