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Bioorg Med Chem Lett. 2001 Feb 12;11(3):415-7.

Nipecotic and iso-nipecotic amides as potent and selective somatostatin subtype-2 receptor agonists.

Author information

1
Merck Research Laboratories, Rahway, NJ 07065, USA. changyou_zhou@merck.com

Abstract

N-Substituted nipecotic and iso-nipecotic amides of beta-methylTrpLys tert-butyl ester were found to be novel, selective and potent agonists of the somatostatin subtype-2 receptor in vitro. For example iso-nipecotic amide 8a showed high hsst2 binding affinity (Ki = 0.5 nM) and good selectivity (h5/h2 = 832).

PMID:
11212124
DOI:
10.1016/s0960-894x(00)00687-9
[Indexed for MEDLINE]

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