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Neuroreport. 2001 Feb 12;12(2):375-8.

First evidence of a delay-dependent working memory-enhancing effect of modafinil in mice.

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Laboratoire de Neurosciences Cognitives, Université de Bordeaux I, UMR CNRS 5601, Talence, France.


This study investigated the effects of pretest injection of modafinil on delayed spontaneous alternation rates (SA) used to evaluate working memory in C57 Bl/6 mice. In a first experiment, systemic modafinil at 64 mg/kg, but not at 8 mg/kg or 32 mg/kg doses produced a significant increase of alternation scores (intertrial interval (ITI) 60s) when compared with controls. In a second experiment, modafinil (64 mg/kg) enhanced the alternation rates mainly at long (60 s and 180 s) but not at short (5 s) ITIs. Exploratory latencies and activity in a four hole-board apparatus were not modified by modafinil administration. These experiments are the first to demonstrate a delay-dependent working memory-enhancing effect of modafinil.

[Indexed for MEDLINE]

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