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Traffic. 2000 Apr;1(4):312-7.

Antigen traffic pathways in dendritic cells.

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Department of Biochemistry, University of Dundee, Dundee, DD1 5EH, UK.


Dendritic cells (DC) are now believed to be the principal initiators of T cell-mediated immune responses. Their location in body tissues, migratory behaviour in response to inflammatory stimuli, endocytic properties, expression of MHC molecules and key T cell stimulatory molecules and many other attributes place these remarkable cells in a unique and influential position in the immune system. Progress in DC culture methods has recently allowed in-depth studies on the cell biological features that enable them to fulfill their crucial role in the immune response.

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