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Genet Res. 2000 Dec;76(3):323-6.

Estimation of microsatellite mutation rates in Drosophila melanogaster.

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Area de Genética, Departamento de Biología Funcional, Universidad de Oviedo, 33071 Oviedo, Spain.


Microsatellite mutations were studied in a set of 175 mutation accumulation lines, all of them independently derived from a completely homozygous population of Drosophila melanogaster and maintained under strong inbreeding during 80 generations. We assayed 28 microsatellites and detected two mutations. One mutation consisted of a single addition of a dinucleotide repeat and the other was a deletion of five trinucleotide repeats. The average mutation rate was 5.1 x 10(-6), in full agreement with previous estimates from two different sets of mutation accumulation lines.

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