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Jpn J Pharmacol. 2000 Dec;84(4):462-6.

Itch-associated responses of afferent nerve innervating the murine skin: different effects of histamine and serotonin in ICR and ddY mice.

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Department of Applied Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan.


To assess the itch-associated response of primary afferents innervating the murine skin in vivo, dose-response curves and time-courses for itch-scratching and cutaneous nerve firing responses to intradermal injections of pruritogens (histamine and serotonin) were compared in ICR and ddY mice. Serotonin increased the itch-scratch response and cutaneous nerve firing in either ICR or ddY mice. Histamine increased these two responses in ICR, but not ddY, mice. The dose-response curves and time-courses for serotonin- and histamine-induced nerve firing were similar to those for the itch-scratch response. The results suggest that cutaneous nerve firing evoked by peripherally given pruritogens includes the itch-associated response.

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