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Therapie. 2000 Sep-Oct;55(5):605-11.

[Drug prescription for pregnant women in the department of the Loire] .

[Article in French]

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Centre de Pharmacovigilance et de Renseignements sur le Médicament, C.H.U. de St-Etienne, Hôpital de Bellevue, Boulevard Pasteur, 42055 Saint-Etienne, France.


A prospective drug prescription and descriptive study was undertaken in a sample of 214 pregnant women in the department of the Loire. This population was randomized using pregnancy declaration files from the French Health Care Centre. Data recording was retrospective. A total of 2064 drugs have been prescribed; 90 per cent of women received at least one drug during the course of pregnancy with an average of 11.5 drugs per woman. Antispasmodics are mainly prescribed in the first trimester while vitamins, mineral supplements, antianemics and vasoactive agents are found in the third trimester. Prescriptions do not rise with age but increase in urban areas. Use of PDD/DDD (Prescribed Daily Dose/Defined Daily Dose) is an estimation of prescription customs. For ketoprofen, it is 1.6 in the last trimester, although this drug is contra-indicated.

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