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Melanoma Res. 2000 Dec;10(6):507-14.

Tumour cell hybridization and metastasis revisited.

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Department of Dermatology, Yale University School of Medicine, New Haven, CT 06520, USA.


This article reviews a long-standing hypothesis that metastases might be initiated through the generation of hybrids between primary tumour cells and tumour-infiltrating leucocytes such as macrophages. In this concept the hybrids become metastatic through expression of the leucocyte motility phenotype. A history of the hybrid hypothesis is presented along with recent evidence on how macrophage x tumour cell hybridization could account for some of the most defining characteristics of metastatic cells: aneuploidy, enhanced motility, aberrant glycosylation and, particularly seen in melanoma, phenotypic diversity.

[Indexed for MEDLINE]

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