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Curr Opin Nephrol Hypertens. 2001 Jan;10(1):19-22.

CD2-associated protein and the kidney.

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Center for Immunology and Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA.


During the past 3 years there have been significant advances in our understanding of the biology of the glomerular podocyte. In particular, two proteins, CD2-associated protein and nephrin, have been identified as critical podocyte proteins that are both required for normal glomerular filtration. In addition to supporting the idea that the slit diaphragm plays a crucial role in glomerular function, these results suggest novel insights into the pathogenesis of glomerular diseases. The present review addresses these recent advances and discusses the implications of the findings.

[Indexed for MEDLINE]

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