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J Endocrinol Invest. 2000 Dec;23(11):721-3.

Delayed closure of epiphyseal cartilages induced by the aromatase inhibitor anastrozole. Would it help short children grow up?

Author information

1
Institute of Endocrine Sciences, Ospedale Maggiore IRCCS, University of Milan, Italy. giovanni.faglia@excite.com

Abstract

Estrogens locally generated from androgen precursors due to the action of aromatase play a main role in epiphyseal cartilage fusion. Treatment with an aromatase inhibitor (anastrozole, 1 mg/day for 3 yr) in a boy previously operated on for a hamartoma causing precocious puberty and presenting with advanced bone maturation and nearly fused epiphyseal cartilages, slowed cartilage fusion consenting a higher final stature than expected (164.4 cm vs 158.4 cm). It is suggested that treatment with aromatase inhibitors, alone or in combination with rh-GH, may also be useful in children with constitutional short stature in order to delay epiphyseal closure and improve the final height.

PMID:
11194703
DOI:
10.1007/BF03345059
[Indexed for MEDLINE]

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