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Diabetes Care. 2001 Jan;24(1):33-8.

MICA polymorphism is associated with type 1 diabetes in the Korean population.

Author information

1
Department of Internal Medicine, Hanyang and Seoul National University, School of Medicine, Korea.

Abstract

OBJECTIVE:

Recent studies have demonstrated that MICA (major histocompatibility complex class I chain-related genes) on the short arm of the chromosome 6 are associated with susceptibility to various autoimmune diseases in Caucasians. The aim of our study was to investigate the role of MICA in type 1 diabetes susceptibility independent of the HLA DR-DQ polymorphism in genetically distinct Koreans.

RESEARCH DESIGN AND METHODS:

A total of 119 patients selected from Korean Seoul type 1 diabetes registry and 134 nondiabetic unrelated control subjects were typed for exon 5 polymorphism of MICA in addition to HLA DR-DQ typing. A total of 52 simplex families of type 1 diabetes were also studied.

RESULTS:

The MICA microsatellite allele consisting of six repetitions of GCT/AGC (A6) was present at a significantly lower frequency in the diabetic patient group (Pc < 0.01; Pc = P value after Bonferroni correction) than in the control population. The MICA microsatellite allele consisting of four repetitions (A4) was present at a higher frequency in diabetic patients (P < 0.05). This deviated distribution was not changed even after controlling for the HLA DRB1-DQB1 haplotype. Transmission/disequilibrium test revealed significant deviation of transmission for alleles at the A6 polymorphism within the MICA gene (P < 0.05).

CONCLUSIONS:

We could assess that the MICA gene might be associated with type 1 diabetes transracially independent of the HLA gene.

PMID:
11194237
[Indexed for MEDLINE]

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