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Ann N Y Acad Sci. 2000;924:1-7.

Genetic factors in the genesis of Alzheimer's disease.

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Department of Medicine (Division of Neurology), University Health Network, University of Toronto, Toronto, Ontario, Canada M5S 3H2.


At least four different genes have been identified that are associated with inherited susceptibiltiy to Alzheimer's disease. Some of the genes are highly penetrant (PS1, PS2, beta APP); the other, APOE, is a weaker susceptibility factor. Several additional genes are suspected to exist but have not yet been cloned.

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