Inhibition by (+)-persenone [corrected] A-related compounds of nitric oxide and superoxide generation from inflammatory leukocytes

O K Kim; A Murakami; Y Nakamura; H W Kim; H Ohigash

doi:10.1271/bbb.64.2500

Inhibition by (+)-persenone [corrected] A-related compounds of nitric oxide and superoxide generation from inflammatory leukocytes

Biosci Biotechnol Biochem. 2000 Nov;64(11):2500-3. doi: 10.1271/bbb.64.2500.

Authors

O K Kim¹, A Murakami, Y Nakamura, H W Kim, H Ohigash

Affiliation

¹ Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Japan.

PMID: 11193427
DOI: 10.1271/bbb.64.2500

Abstract

We have previously reported that persenone A, isolated from avocado fruit, is an effective inhibitor of both nitric oxide (NO) and superoxide (O2-) generation in cell culture systems. In this study, we have prepared four persenone A-related compounds and examined their inhibition of NO and O2- generation from inflammatory leukocytes. Some structural importance in persenone A to attenuate free radical generation is discussed.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Esters / chemical synthesis
Esters / chemistry
Esters / pharmacology*
Fatty Alcohols / chemical synthesis
Fatty Alcohols / chemistry
Fatty Alcohols / pharmacology*
Humans
Lauraceae / chemistry*
Leukocytes / drug effects*
Leukocytes / metabolism
Nitric Oxide / metabolism*
Superoxides / metabolism*

Substances

Esters
Fatty Alcohols
persenone A
Superoxides
Nitric Oxide
persenone B