Send to

Choose Destination
Science. 2000 Oct 27;290(5492):721-4.

Biomedicine. Combating Parkinson's disease--step three.

Author information

Department of Neuroscience, Karolinska Institute, 171 77 Stockholm, Sweden.


The degeneration of dopamine neurons in the nigrostriatal pathway of the brain results in the debilitating motor deficits of Parkinson's disease. In a Perspective, Olson discusses a new study (Kordower et al.) demonstrating that injection of a lentiviral vector containing the gene encoding GDNF (a trophic factor for dopamine neurons) into the nigrostriatal pathway of monkeys with PD prevents neuronal loss and reverses some of the motor deficits of this disease.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for HighWire
Loading ...
Support Center