Format

Send to

Choose Destination
See comment in PubMed Commons below
Genome Biol. 2001;2(2):REVIEWS3003. Epub 2001 Feb 7.

ClC chloride channels.

Author information

1
Howard Hughes Medical Institute and Department of Biochemistry, Brandeis University, Waltham, MA 02454, USA. jmindell@brandeis.edu

Abstract

SUMMARY:

Chloride-conducting ion channels of the ClC family are emerging as critical contributors to a host of biological processes. These polytopic membrane proteins form aqueous pathways through which anions are selectively allowed to pass down their concentration gradients. The ClCs are found in nearly all organisms, with members in every mammalian tissue, yet relatively little is known about their mechanism or regulation. It is clear, however, that they are fundamentally different in molecular construction and mechanism from the well-known potassium-, sodium-, and calcium-selective channels. The medical importance of ClC channels - four inherited diseases have been blamed on familial ClC dysfunction to date - highlights their diverse physiological functions and provides strong motivation for further study.

PMID:
11182894
PMCID:
PMC138906
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for PubMed Central
    Loading ...
    Support Center