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Chem Biol. 2001 Jan;8(1):1-7.

Locked nucleic acid (LNA): fine-tuning the recognition of DNA and RNA.

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  • 1Departments of Pharmacology and Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9041, USA.


Locked nucleic acid is an RNA derivative in which the ribose ring is constrained by a methylene linkage between the 2'-oxygen and the 4'-carbon. This conformation restriction increases binding affinity for complementarity sequences and provides an exciting new chemical approach for the control of gene expression and optimization of microarrays.

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