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Endocrinology. 2001 Mar;142(3):1073-81.

Limited redundancy of survival signals from the type 1 insulin-like growth factor receptor.

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Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.


The type 1 insulin-like growth factor receptor (IGF-IR) is effective in protecting cells from a variety of apoptotic injuries. In 32D murine hemopoietic cells, the IGF-IR sends three separate survival signals, through insulin receptor substrate-1, Shc, and mitochondrial Raf translocation. We report here that these three pathways for survival have a limited redundancy. If one of these pathways is blocked, the IGF-IR can still protect 32D cells from apoptosis induced by interleukin-3 withdrawal. However, when two of the three pathways are inactivated, the receptor is no longer capable to protect cells from apoptosis. The survival signal can use any two pathway combinations.

[Indexed for MEDLINE]

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