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J Infect Dis. 2001 Mar 1;183(5):810-3. Epub 2001 Jan 24.

A cohort study of health care workers to assess nosocomial transmissibility of Nipah virus, Malaysia, 1999.

Author information

1
Respiratory and Enteric Viruses Branch, Centers for Disease Control and Prevention, US Department of Health and Human Services, Atlanta, GA 30333, USA.

Abstract

During 1998-1999, an outbreak of Nipah virus encephalitis occurred in Malaysia. To assess the possibility of nosocomial transmission, 338 health care workers (HCWs) exposed and 288 HCWs unexposed to outbreak-related patients were surveyed, and their serum samples were tested for anti-Nipah virus antibody. Needlestick injuries were reported by 12 (3%) HCWs, mucosal surface exposure to body fluids by 39 (11%), and skin exposure to body fluids by 89 (25%). No encephalitis occurred in either group. Three exposed and no unexposed HCWs tested positive by EIA for IgG antibodies. It is likely that these 3 were false positives; no IgM response occurred, and the serum samples were negative for anti-Nipah virus neutralizing antibodies. The risk of nosocomial transmission of Nipah virus appears to be low; however, given the high case-fatality rate and the presence of virus in respiratory secretions and urine of some patients, standard and droplet infection-control practices should be maintained with these patients.

PMID:
11181159
DOI:
10.1086/318822
[Indexed for MEDLINE]

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