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Stat Med. 2001 Feb 15;20(3):391-9.

Cluster trials in implementation research: estimation of intracluster correlation coefficients and sample size.

Author information

1
Health Services Research Unit, University of Aberdeen, Aberdeen, UK. m.k.campbell@abdn.ac.uk

Abstract

The cluster randomized trial with a concurrent economic evaluation is considered the gold standard evaluative design for the conduct of implementation research evaluating different strategies to promote the transfer of research findings into clinical practice. This has implications for the planning of such studies, as information is needed on the effects of clustering on both effectiveness and efficiency outcomes. This paper describes the design considerations specific to implementation research studies, focusing particularly on the estimation of sample size requirements and on the need for reliable information on intracluster correlation coefficients for both effectiveness and efficiency outcomes.

PMID:
11180309
[Indexed for MEDLINE]
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